A heat shock protein gene inGiardia lambliaunrelated to HSP70

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molecular characterization of a 70 kda heat shock protein (hsp70) gene in entamoeba dispar

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A heat shock protein gene in Giardia lamblia unrelated to HSP70.

A 4.2 kb Hindin gene fragment from Giardia lamblia trophozoites strain WB, selected by P labeled HSP70 clone pPW229 of Drosophila (1) was cloned into pUC19 (pUCG2c). The sequence was determined by sequencing both strands of overlapping restriction fragments. The sequence contains a 5' non-coding region of 141 bases followed by 1593 nucleotides showing a single continuous open reading frame star...

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Compound A, a Selective Glucocorticoid Receptor Modulator, Enhances Heat Shock Protein Hsp70 Gene Promoter Activation

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expression. The heat shock response potently activates heat shock factor 1 (HSF1), upregulates Hsp70, a k...

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The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

Transcriptional regulation of the human hsp70 gene in response to heat shock and other forms of physiological stress occurs through the activation of heat shock transcription factor (HSF). Exposure of cells to a heat shock temperature of 42 degrees C results in transient activation of HSF; its DNA-binding activity increases rapidly, plateaus, and attenuates, during which the intracellular level...

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Genetic determinants of HSP70 gene expression following heat shock

The regulation of heat shock protein expression is of significant physiological and pathophysiological significance. Here we show that genetic diversity is an important determinant of heat shock protein 70 expression involving local, likely cis-acting, polymorphisms. We define DNA sequence variation for the highly homologous HSPA1A and HSPA1B genes in the major histocompatibility complex on chr...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 1990

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/18.11.3409